SCN1A Variants in vaccine-related febrile seizures: A prospective study

JA Damiano; L Deng; W Li; R Burgess; AL Schneider; NW Crawford; J Buttery; M Gold; P Richmond; KK Macartney; MS Hildebrand; IE Scheffer; N Wood; SF Berkovic

Journal article

SCN1A Variants in vaccine-related febrile seizures: A prospective study

JA Damiano, L Deng, W Li, R Burgess, AL Schneider, NW Crawford, J Buttery, M Gold, P Richmond, KK Macartney, MS Hildebrand, IE Scheffer, N Wood, SF Berkovic

Annals of Neurology | WILEY | Published : 2020

DOI: 10.1002/ana.25650

Download PDF

Abstract

Objective: Febrile seizures may follow vaccination. Common variants in the sodium channel gene, SCN1A, are associated with febrile seizures, and rare pathogenic variants in SCN1A cause the severe developmental and epileptic encephalopathy Dravet syndrome. Following vaccination, febrile seizures may raise the specter of poor outcome and inappropriately implicate vaccination as the cause. We aimed to determine the prevalence of SCN1A variants in children having their first febrile seizure either proximal to vaccination or unrelated to vaccination compared to controls. Methods: We performed SCN1A sequencing, blind to clinical category, in a prospective cohort of children presenting with their f..

View full abstract

University of Melbourne Researchers

Amy Schneider Author

Nigel Crawford Author

Jim Buttery Author

Michael Hildebrand Author

Related Projects (5)

GENETICS OF EPILEPSIES AND SPEECH DISORDERS

Epilepsy and speech disorders are common diseases in the Australian population that have major genetic contributions. To improve clinical ca..

GENETICS OF EPILEPSY

Professor Scheffer and her collaborators lead the world in the discovery of the genetic causes of epilepsy. She will continue to identify ne..

EXPLORING SOMATIC MUTATION IN FOCAL EPILEPSIES

Epilepsy is a common disease in the Australian population affecting 3 percent of individuals. It incurs lifelong medical, social and educati..

HUMAN EPILEPSY: UNDERSTANDING BIOLOGY TO IMPROVE OUTCOMES

Our team of neurologists, molecular geneticists, physiologists and brain imaging specialists and leads the world in the discovery of the gen..

DETECTION OF SOMATIC MUTATIONS IN SPORADIC EPILEPSIES

Finding genetic causes of epilepsies is essential for refining treatments and genetic counseling. Genetic mutations may occur after fertiliz..

Grants

Awarded by University of Sydney

Funding Acknowledgements

This study is supported by National Health and Medical Research Council (NHMRC) Project Grant 1049557, NHMRC Program Grant 1091593 to S.F.B and I.E.S, NHMRC Practitioner Fellowship 1006110 to I.E.S, NHMRC Project Grant 1129054 to S.F.B, NHMRC Career Development Fellowship 1063629 to N.W, a University of Sydney Research Training Program scholarship to L.D., and NHMRC Project Grant 1079058 and NHMRC R. D. Wright Career Development Fellowship 1063799 to M.S.H.